Post-Doc Research Associate
University of North Carolina at Chapel Hill

Job Info

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Department:

Lineberger Compr Cancer Center - 426801

Posting Open Date:

12/23/2024

Application Deadline:

12/30/2024

Open Until Filled:

No

Position Type:

Postdoctoral Scholar

Position Title:

Post-Doc Research Associate

Vacancy ID:

PDS004423

Full-time/Part-time:

Full-Time Temporary

Hours per week:

40

FTE:

1

Work Location:

Chapel Hill, NC

Position Location:

North Carolina, US

Hiring Range:

Dependent on Qualifications/Experience

Proposed Start Date:

02/01/2025

Estimated Duration of Appointment:

12 Months

Be a Tar Heel!:

A global higher education leader in innovative teaching, research and public service, the University of North Carolina at Chapel Hill consistently ranks as one of the nation's top public universities and is among is the top ten research universities in the nation for federal research expenditures as well as for federally funded social and behavioral sciences research and development.Here at Carolina, our highly skilled postdocs play a vital role in our research enterprise and towards our overall commitment to research excellence. Across many disciplines, postdocs contribute to the intellectual vitality of the University. They provide innovative ideas and perspectives, foster a stimulating research environment and advance knowledge within their fields. Postdocs are crucial members of our scientific research workforce, contributors to our research outputs and an important reason why Carolina is one of the leading public research institutions in the country.UNC-Chapel Hill offers postdocs comprehensive medical and vision coverage, paid leave, and benefits and services that support professional development and a healthy work/life balance. Chapel Hill regularly ranks as one of the best college towns and best places to live in the United States, a reputation guided by the diverse social, cultural, recreation and professional opportunities that span the campus and community.

Primary Purpose of Organizational Unit:

The UNC School of Medicine has a rich tradition of excellence and care. Our mission is to improve the health and wellbeing of North Carolinians, and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research. We strive to promote faculty, staff, and learner development in a diverse, respectful environment where our colleagues demonstrate professionalism, enhance learning, and create personal and professional sustainability. We optimize our partnership with the UNC Health System through close collaboration and commitment to service.
OUR VISION
Our vision is to be the nation's leading public school of medicine. We are ranked 2nd in primary care education among all US schools of medicine and 5th among public peers in NIH research funding. Our Allied Health Department is home to five top-ranked divisions, and we are home to 18 top-ranked clinical and basic science departments in NIH research funding.
OUR MISSION
Our mission is to improve the health and well-being of North Carolinians and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research.
Patient Care: We will promote health and provide superb clinical care while maintaining our strong tradition of reaching underserved populations and reducing health disparities across North Carolina and beyond.
Education: We will prepare tomorrow's health care professionals and biomedical researchers by facilitating learning within innovative curricula and team-oriented interprofessional education. We will cultivate outstanding teaching and research faculty, and we will recruit outstanding students and trainees from highly diverse backgrounds to create a socially responsible, highly skilled workforce.
Research: We will develop and support a rich array of outstanding health sciences research programs, centers, and resources. We will provide infrastructure and opportunities for collaboration among disciplines throughout and beyond our University to support outstanding research. We will foster programs in the areas of basic, translational, mechanistic, and population research.

Position Summary:

This post-doctoral position will lead studies focused on signaling pathways involved in tumor-mediated dendritic cell tolerization and the induction of dendritic cell dysfunction in the tumor microenvironment. This will involve the use of various molecular cloning techniques to genetically manipulate dendritic cells and the execution of various immunologic methods to examine the impact of this manipulation on the anti-tumor immune response. This work will involve lentiviral engineering, flow cytometry, basic sterile tissue culture techniques, immune cell isolation and purification, qrt-PCR, Western blot, ELISA, as well as the use of single-cell RNAseq transcriptional analysis. Finally, this position will also involve murine tumor studies that include tumor inoculation, monitoring, and performing correlative analysis of the anti-tumor immune response. This individual may occasionally be asked to mentor graduate students and undergraduates as well.

Minimum Education and Experience Requirements:

PhD in the Biomedical Sciences.

Required Qualifications, Competencies, and Experience:

* Extensive experience with molecular cloning and lentiviral engineering
* Extensive experience with immune cell isolation and purification using both FACS and magnetic bead technologies.
* Extensive experience with multi-parameter flow cytometry
* Extensive experience with qrt-PCR, PCR, Western blot, and ELISA
* Extensive experience with animal handling and in vivo tumor studies

Preferred Qualifications, Competencies, and Experience:

* Preferred experience performing and analyzing single-cell RNAseq

Special Instructions:

For information on UNC Postdoctoral Benefits and Services click here

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