Scientist, Immunology Cell Therapy Discovery
AstraZeneca

Job Info

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Scientist, Immunology Cell Therapy Discovery

AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Immunology Cell Therapy Discovery is centered on delivering life-changing products with the potential to cure immune-mediated diseases. As part of the growing Immunology Cell Therapy Discovery team, you will have the opportunity to make a meaningful difference in people's lives every day.

We are seeking a highly motivated Scientist with a strong background in immunology and/or cell therapy to join our team. This is a lab-based position located in Waltham, Massachusetts, within AstraZeneca's state-of-the-art laboratories. Here, you will follow the science to help drive innovation and advance medicines to improve patients' lives. This position offers a unique opportunity to work in a dynamic and innovative environment, developing your career at the interface of research and drug discovery.

Accountabilities

We are looking for a team player who is self-motivated and passionate about innovative scientific research leading to the discovery and development of novel therapeutics. Expertise in primary cell culture and assay development is essential. Skills in flow cytometry, multiplex cytokine read-outs, qPCR, and in vitro/ex vivo culture of immune cells are strongly preferred.

You will contribute to developing novel cell therapies for immunological diseases by supporting assay development, target identification, target validation, and drug development. You will primarily work with human immune cells from healthy donors and patients in vitro. Thus, expertise in primary cell culture, functional assays, and assay development as well as solid experience with multi-color flow cytometry is essential. Hands-on experience with tissue-derived immune cells is strongly preferred. Familiarity with molecular biology techniques, in vitro 3D models, or human tissue samples is a plus.

You will work closely with highly accomplished scientists across different functional teams and locations, benefiting from their support and mentorship.

Essential Skills/Experience

• BS degree in biology, immunology or a relevant discipline with 5+ years of industry experience.
• Expertise working with human immune cells and their phenotypic and functional characterization is essential.
• Deep experience in multi-color flow-cytometry, including panel development is required.
• Experience in development of cell therapy candidates is preferred.
• Hands-on skills with in vitro 3D models and/or primary human tissues are a big plus.
• Experience with other cell biology and molecular biology techniques, such as lenti/retroviral transductions, cloning, gene editing (CRISPR KO/KI), qPCR, ddPCR, stable cell line generation, is a plus.
• Demonstrated ability to work productively in a dynamic and collaborative environment.
• Ability to critically analyze datasets is essential.
• Attention to detail and recording of protocols and experiments in a timely manner.

Desirable Skills/Experience

• MS degree in biology, immunology or a relevant discipline with 5+ years of industry experience.

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our team is dedicated to following the science with curiosity, passion, and determination. We are committed to making bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next.

Join us on our mission to make big paradigm shifts in treatment options by identifying and treating patients earlier. Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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