Senior Scientist
Eurofins Lancaster Laboratories Professional Scientific Services, LLC

Job Info

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Senior Scientist

Employee Responsibilities:

• High-res LCMSMS method development for global profiling of lipids in biological samples.
• Work with analytical instrumentation, especially with LC - High Resolution Mass spectrometry, LC-MS/MS methodology for targeted analysis of lipids and other endogenous biomolecules (including proteins); the knowledge of analytical work in the regulated environment .
• Build Lipid data bases and analysis of lipid pathways.
• Conduct biomarker validation studies within industry standards for identification and validation of biomarkers.
• Maintenance, cleaning, tuning and troubleshooting of advanced mass spectrometers (triple quadrupole and high resolution Orbitrap mass specs).
• Development and implementation of LC-MS profiling methods, and quantitative analysis of endogenous biomolecules.
• Conduct experiments for elucidation of structures for metabolic biomarkers.
• Work with Compound Discoverer, Progenesis, Mass Profiler Professional and Expressionist platforms for processing of metabolomics and proteomics data.
• Utilization of publically available Lipid data bases, especially Lipid Maps.
• Analyze and report on affected metabolic pathways.
• Develop internal biomarkers database and metabolomics data processing software.
• Develop high-res LCMSMS methods for specific biomarkers in biological matrices and analyze samples as required.
• Apply analytical results to target credentialing and mechanism of action studies, phenotypic screens, design of in-vitro studies and establishment of disease biomarkers.
• Manage and operate high-res LCMSMS instrumentation.
• Develop LV-High Resolution MS and LC-MS/MS methods for global profiling of lipids in biological samples.
• Carry out analysis of the affected metabolic pathways and report the data to the project teams.
• Participate in the work of client's metabolomics team by contributing in development of internal biomarkers data base, and metabolomics data processing software, including collaborating with instrument/software vendors.
• Conduct metabolic biomarker discovery work which will guide teams supporting high priority projects by LC-High Res MS methodology KPI: provide timely updates and results summary in the form of oral presentations, PowerPoint summaries, Excel reports, and custom reports generated in Client's data processing platform.
• Develop and run targeted LC-MS/MS methods for analysis of identified lipid markers in biological samples.
• Support client's target credentialing and mechanism of action studies, establishment of phenotypic screens, establishment and validation of animal models as well as clinical studies with Lipidomics and targeted lipid analysis and LC-MS analysis of proteins.
• Participate in establishment of disease biomarkers suitable for monitoring of disease progression and effectiveness of treatment.
• Upon need for support of establishment and conducting LC-MS based phenotypic screens using multiplex LC-MS instruments.

The Ideal Candidate would possess:

• Strong computer, scientific, and organizational skills
• Excellent communication (oral and written) and attention to detail
• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies

Minimum Qualifications:

• BS/MSPhD in science related discipline
• Experience with LC/MS/MS method development
• Experience building Lipid data bases and analysis of lipid pathways
• Authorization to work in the United States indefinitely without restriction or sponsorship

What we offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Position is full-time, Monday-Friday, 8 a.m.-5 p.m., with overtime as needed. Candidates currently living within a commutable distance of Waltham, MA are encouraged to apply.

Eurofins Lancaster Laboratories Professional Scientific Services ® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.

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